Mean arterial blood pressure (BPm), heart rate, and intraocular pressure (IOP) were monitored, and ocular perfusion pressure (PP) was estimated. In the last six subjects, additional measurements were obtained at 3 hours. Ch flow and ON flow were determined monocularly at baseline and 1 hour after dosing.
In a double masked, randomised, crossover design, each subject received orally on separate days either 20 mg of 5-isosorbide mononitrate (ISMO) or placebo. METHODS Laser Doppler flowmetry was used to measure ON flow and Ch flow in 12 normal subjects by aiming the laser beam at the fovea and at the temporal rim, respectively. Make sure laboratory personnel and all your doctors know you use this drug.AIMS To assess the effects of the nitric oxide donor 5-isosorbide mononitrate (ISMO) on blood flow in the optic nerve head (ON flow) and choroid (Ch flow). This medication may interfere with certain laboratory tests (including cholesterol levels), possibly causing false test results. Do not use medications containing isosorbide dinitrate while using isosorbide mononitrate. Isosorbide mononitrate is very similar to isosorbide dinitrate.
ISOSORBIDE MONONIT ER HOW TO
Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Some products have ingredients that could worsen your heart failure. Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), riociguat. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. This document does not contain all possible drug interactions. You may report side effects to Health Canada at 1-86.ĭrug interactions may change how your medications work or increase your risk for serious side effects. You may report side effects to FDA at 1-80 or at In Canada - Call your doctor for medical advice about side effects. In the US - Call your doctor for medical advice about side effects. If you notice other effects not listed above, contact your doctor or pharmacist. This is not a complete list of possible side effects. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. A very serious allergic reaction to this drug is rare. Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat. Many people using this medication do not have serious side effects. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. This effect is harmless since your body has already absorbed the medication. An empty tablet shell may appear in your stool. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. If headaches continue or become severe, tell your doctor promptly. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). Headache is often a sign that this medication is working.
If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Headache, dizziness, lightheadedness, nausea, and flushing may occur as your body adjusts to this medication. Tell your doctor if this medication stops working well (for example, you have more frequent or worsening chest pain). Although unlikely, when this medication is used for a long time, it may not work as well and may require different dosing. Your dose may need to be gradually decreased. Some conditions may become worse when the drug is suddenly stopped. Do not stop taking it without consulting your doctor. To help you remember, take it at the same time each day. Use this medication regularly to get the most benefit from it. Swallow the whole or split tablet without crushing or chewing. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so.
Doing so can release all of the drug at once, increasing the risk of side effects. Swallow this medication whole with a half glass of water (4 ounces/120 milliliters) unless your doctor directs you otherwise. Take this medication by mouth as directed by your doctor, usually once daily when you wake up.